Baucum Laboratory


The Baucum laboratory located in the Department of Pharmacology and Toxicology at Indiana University School of Medicine on the IUPUI campus focuses on the functional regulation of the highly promiscuous phosphatase, protein phosphatase 1 (PP1) by the major homologous synaptic PP1 targeting proteins, spinophilin and neurabin. The overarching goal is to understand how these proteins regulate both PP1 targeting to, and activity at, specific substrates.

We focus on the role of spinophilin and neurabin in multiple brain regions and within the periphery. Currently, our studies focus on the striatum, hippocampus, and cerebellum within the brain and the pancreatic islets within the periphery. We strive to provide mechanistic insight into both normal PP1 signaling as well as how this signaling is perturbed in myriad disorders, neurodivergences, and disease states, including: drug use and misuse, parkinson disease, ataxias, and obesity and diabetes.


Summer/Fall 2022:

September - Dr. Darryl Watkins starts his postdoc position in the Andre Fenton Laboratory at NYU

September - Dr. Cameron Morris starts his postdoc position in the Nicole Calakos Laboratory at Duke

August - Mr. Wesley Corey starts his Ph.D. at Drexel University School of Medicine

June/July - Basant Hens and Nikhil Shah join the Baucum Laboratory. Basant is a PhD student in the Pharmacology and Toxicology Department and Nikhil is an MD/PhD student in the Medical Neurosciences program

June - Emily Claeboe joined the lab as a technician